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Figure 2 | Molecular Pain

Figure 2

From: Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain

Figure 2

MOR in primary sensory neuron and its terminals were decreased in neuropathic mice. (A, B) Western blot shows that MOR protein were markedly decreased in sciatic nerve (A) and hindpaw skin (B) on day 7 after nerve injury when compared with sham-operated mice. The ratio of MOR/GAPDH in sham mice was set at 1 for quantifications. *p <0.05, **p <0.01, n=4 in each group. (C-F) Immunofluorescence staining shows that decreased MOR-labeled neurons in DRG (C) and spinal cord dorsal horn (D), decreased MOR-labeled nerve fibers in the sciatic nerve (E) and hindpaw skin (F) on day 7 after nerve injury. Scales bars= 100 μm.

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