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Figure 3 | Molecular Pain

Figure 3

From: Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain

Figure 3

5-aza-dC improved morphine analgesia in neuropathic mice. (A) i.t. 5-aza-dC (5 μg, daily for 3 consecutive days, starting 30 minutes before surgery) improved the effects of s.c. 1 mg/kg morphine in nerve-injured mice on days 3, 7 and 14 after surgery. Results are presented as TWL at 30 min after s.c. injection of morphin. *p <0.05, **p <0.05 compared with CCI-Vehicle, n=8 mice in each group. (B-D) Dose–response curves of s.c. (B), i.t. (C) and i.pl. (D) morphine in nerve-injured and 5-aza-dC treatmented mice on day 7 after nerve injury. The data are presented as AUC analgesic. *p <0.05 compared with CCI-Vehicle, n=8 mice in each group.

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Molecular Pain

ISSN: 1744-8069

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