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Figure 6 | Molecular Pain

Figure 6

From: Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain

Figure 6

MOR in peripheral sensory neuron and its terminals were increased after treatment with 5-aza-dC. (A, B) Western blot shows that MOR protein were markedly increased in sciatic nerve (A) and hindpaw skin (B) after treatment with 5-aza-dC (5 μg, daily for 3 consecutive days, starting 30 minutes before surgery and detected on day 7 after nerve injury) when compared with CCI-Vehicle mice, *p <0.05, **p <0.01, n=4 in each group. (C-F) Immunofluorescence staining shows that increased MOR-labeled neurons in DRG (C) and spinal cord dorsal horn (D), increased MOR-labeled nerve fibers in the sciatic nerve (E) and hindpaw skin (F) after treatment with 5-aza-dC (5 μg, daily for 3 consecutive days, starting 30 minutes before surgery). Scales bars= 100 μm.

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Molecular Pain

ISSN: 1744-8069

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