Figure 3

Histopathology of the medial condyle of the femur and tibia with or without 2ccPA treatment. Hematoxylin and eosin (HE)- and Safranine (Saf)-O–stained sections of the cartilage of the right medial condyle of the femur and tibia on Day 42 after surgery. Original magnification × 10 (A), ×200 (B), and × 600 (C1 and C2). Disorganization of chondrocytes (black circles), exposure of subchondral bone (black arrowheads), cluster formation (blue arrowheads), loss of chondrocytes (green arrowheads), loss of the superficial layer (yellow arrowheads), and fissure (red arrowhead) are shown.