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Figure 1 | Molecular Pain

Figure 1

From: Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Figure 1

Administration of paclitaxel causes activation of microglia in the SDH. (A) Threshold for withdrawal in response to mechanical stimulation to the hindpaw before and after injection of vehicle or paclitaxel (**P < 0.01, *** P < 0.001 vs. vehicle group, n = 6). (B) Immunofluorescence for Iba1, a marker of microglia, in the SDH of vehicle (control)- or paclitaxel-treated rats (Scale bar, 200 μm). Insets: high magnification images (Scale bar, 20 μm). (C) The number of microglia labeled with Iba1 per 6 × 105 μm in the SDH of paclitaxel-treated rats (n = 3, **P < 0.01, ***P < 0.001, vs. naïve control rats). Values are means ± s.e.m.

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Molecular Pain

ISSN: 1744-8069

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