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Figure 4 | Molecular Pain

Figure 4

From: Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Figure 4

P2X7Rs are upregulated by paclitaxel treatment and contribute to mechanical allodynia. (A) Real-time RT-PCR analysis of P2X7R mRNA in the SDH of paclitaxel- and vehicle-treated rats 7 days after the first injection of paclitaxel (n = 6, ***P < 0.001). Values represent the relative ratio of P2X7R mRNA (normalized to the level of GAPDH mRNA) in paclitaxel-treated rats to that in vehicle control rats (fold change over control rats). (B) A438079 (a selective P2X7R antagonist; 1 μmol/10 μL) was intrathecally administered once a day for 7 days (from a day before the first paclitaxel injection to day 7) (n = 6, ***P < 0.001, vs. vehicle-treated control group). (C) A438079 (1000 nmol/10 μL) was intrathecally administered once on day 7 (n = 6, *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle-treated control group). Values are means ± s.e.m.

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Molecular Pain

ISSN: 1744-8069

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