Figure 1

Impact of cisplatin on body weight, body temperature, mechanical and cold allodynia in groups pretreated with antioxidant treatments (NaHCO ₃ , vitamin C, resveratrol) or saline. (A) Body weight and (B) body temperature did not differ between groups receiving saline in lieu of cisplatin with different (saline, NaHCO₃, vitamin C, resveratrol) pretreatments and were pooled into a single control/saline group. (A) Body weight and (B) body temperature was lowest in cisplatin-treated rats receiving saline or resveratrol pretreatment. Vitamin C and NaHCO₃ attenuated cisplatin-induced decreases in body temperature. Time course of development of (C) mechanical and (D) cold allodynia in cisplatin-treated groups pretreated with saline, NaHCO₃, vitamin C or resveratrol. Mechanical and cold sensitivity did not differ between groups receiving saline in lieu of cisplatin with different (saline, NaHCO₃, vitamin C, resveratrol) pretreatments and were pooled into a single control/saline group. Arrows show timing of injections of chemotherapeutic agents. Data are expressed as mean ± s.e.m. (n = 9–18 per group). *P < 0.0001 for saline, NaHCO₃, vitamin C or resveratrol/cisplatin-treated groups vs. control saline group (ANOVA, Bonferroni post hoc); + P < 0.048 for vitamin C vs. resveratrol/cisplatin group (ANOVA, Bonferroni post hoc); # P < 0.0001 for saline or resveratrol/cisplatin-treated groups vs. control saline group (ANOVA, Bonferroni post hoc); ^ P < 0.007 for vitamin C or NaHCO₃/cisplatin groups vs. saline/cisplatin group (ANOVA, Bonferroni post hoc).