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Figure 3 | Molecular Pain

Figure 3

From: Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status

Figure 3

Kidney functions assessment in saline or cisplatin-treated groups receiving different pretreatments (saline, NaHCO 3, vitamin C, or resveratrol). (A) Creatinine levels were increased in saline/cisplatin and resveratrol/cisplatin groups relative to control/saline treatment. Both vitamin C and NaHCO3 pretreatments blocked cisplatin-induced increases in creatinine levels. (B) Ketone levels are increased in saline/cisplatin group but not in control/saline, vitamin C, NaHCO3 or resveratrol/cisplatin-treated groups. (C) Glucose levels and (D) blood pH did not differ between control/saline or any cisplatin-treated group. (E) Urine pH was elevated in the NaHCO3/cisplatin group in comparison to control/saline, saline/cisplatin or vitamin C/cisplatin groups. (F) Kidney weight ratios are increased in saline/cisplatin and resveratrol/cisplatin groups relative to control/saline, vitamin C or NaHCO3 treated groups. Data are expressed as mean ± s.e.m. (n = 8 per group). *P < 0.001 vs. control/saline, vitamin C or NaHCO3/cisplatin groups (ANOVA, Bonferroni post hoc); + P < 0.0001 vs. control/saline, vitamin C, NaHCO3 or resveratrol/cisplatin-treated groups (ANOVA, Bonferroni post hoc); # P < 0.0001 vs. control saline, saline/cisplatin or vitamin C/cisplatin groups (ANOVA, Bonferroni post hoc).

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Molecular Pain

ISSN: 1744-8069

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