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Figure 4 | Molecular Pain

Figure 4

From: Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status

Figure 4

mRNA levels of inflammatory cytokines (IL-1β, IL-6, IL-10 and TNFα) in lumbar spinal cord and kidneys. IL-1β (A) mRNA levels are increased in lumbar spinal cord of saline, NaHCO3 or resveratrol/cisplatin-treated groups relative to the control/saline or vitamin C/cisplatin groups. Resveratrol/cisplatin group exhibited higher IL-1β mRNA levels relative to vitamin C/cisplatin group (A). IL-6, TNFα and IL-10 spinal cord mRNA levels did not differ reliably between groups. (B) In the kidneys, levels of IL-6 and TNFα mRNAs were higher in cisplatin-treated mice compared to the control/saline group. Resveratrol/cisplatin group shows higher IL-6 and TNFα mRNA levels relative to control/saline group. IL-1β and IL-10 mRNA levels in the kidneys did not differ reliably between groups (B). Data are expressed as mean ± s.e.m. (n = 4 per group). *P < 0.041 vs. control/saline or vitamin C/cisplatin (ANOVA, Bonferroni post hoc); + P < 0.046 for resveratrol/cisplatin group vs. vitamin C/cisplatin-treated group (ANOVA, Bonferroni post hoc); ^ P < 0.045 vs. control/saline group (ANOVA, Bonferroni post hoc); # P < 0.043 for resveratrol/cisplatin group vs. control saline group (ANOVA, Bonferroni post hoc).

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Molecular Pain

ISSN: 1744-8069

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