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Figure 5 | Molecular Pain

Figure 5

From: Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status

Figure 5

Long term effects of cisplatin on body weight, body temperature, mechanical and cold allodynia in control/saline, saline/cisplatin or vitamin C/cisplatin groups. Weight gain (A) is decreased in cisplatin-treated mice from day 12 to day 52 relative to control saline group. On day 36, saline/cisplatin exhibit lower body temperature than vitamin C/cisplatin group. Weight gain is similar in saline or cisplatin-treated groups from day 56 to 96. Body temperature (B) did not differ in the control/saline group relative to vitamin C/cisplatin group at any observation interval (from day 0 to day 96). Indeed,vitamin C pretreatment blunted cisplatin-induced decreases in body temperature. Time course of development of mechanical (C) and cold (D) allodynia in cisplatin-treated groups pretreated with saline or vitamin C. Arrows show timing of injections of chemotherapeutic agents. Data are expressed as mean ± s.e.m. (n = 6–8 per group). *P < 0.03 vs. control/saline group (ANOVA, Bonferroni post hoc); + P < 0.018 for vitamin C/cisplatin vs. saline/cisplatin group (ANOVA, Bonferroni post hoc); # P < 0.041 vs. control/saline or vitamin C/cisplatin-treated groups (ANOVA, Bonferroni post hoc).

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Molecular Pain

ISSN: 1744-8069

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