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Figure 7 | Molecular Pain

Figure 7

From: Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status

Figure 7

Long term effects on mRNA levels of inflammatory cytokines (IL-1β, IL-6, IL-10 and TNFα) in the lumbar spinal cord and kidneys. IL-1β mRNA levels are decreased in vitamin C/cisplatin treated group relative to control/saline group in the lumbar spinal cord (A). IL-1β mRNA levels in spinal cord were similar in control/saline and saline/cisplatin groups. IL-6, TNFα or IL-10 mRNA levels were not altered in the spinal cord of control/saline, saline/cisplatin or vitamin C/cisplatin groups (A). No changes were observed in mRNA levels of TNFα, IL-6, IL-1β and IL-10 in the kidneys (B) of control/saline, saline/cisplatin or vitamin C/cisplatin groups. Tissue was harvested 60 days following the last cisplatin dose. Data are expressed as mean ± s.e.m. (n = 4 per group). *P < 0.024 vs. control/saline group (ANOVA, Bonferroni post hoc).

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Molecular Pain

ISSN: 1744-8069

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