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Figure 2 | Molecular Pain

Figure 2

From: Transient receptor potential ankyrin 1 in spinal cord dorsal horn is involved in neuropathic pain in nerve root constriction rats

Figure 2

Effects of HC-030031 on root constriction (RC)-induced mechanical hypersensitivity, hyperalgesia, and spontaneous pain. The time course for mechanical hypersensitivity and mechanical hyperalgesia in the RC rats, sham rats, and naïve rats after HC-030031 treatment (10 μg, intrathecally). (A) The response rate evaluated by a 3.2-g von Frey test was significantly decreased by HC-030031 treatment in the RC rats but did not change in the sham rats and naïve rats. Intrathecal injection of vehicle had no effect in any of the groups. (B) The response rate evaluated by pin-prick test was significantly decreased by HC-030031 treatment in the RC rats, sham rats, and naïve rats. Intrathecal injection of vehicle also had no effect in any of the groups. *P < 0.05 compared with RC + vehicle, +/#P < 0.05 compared with naïve + vehicle; one-way factorial measures of analysis of variance followed by Tukey–Kramer test. (C) Intrathecal injection efficacy was calculated by dividing the response rate after HC-030031 treatment by the response rate at baseline. There was no statistical difference among the RC rats, sham rats, and naïve rats. (D) The degree of spontaneous pain-related behavior was significantly decreased after HC-030031 treatment. Pre-From = before drug injection. *P < 0.05 (Mann–Whitney U test).

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