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Figure 5 | Molecular Pain

Figure 5

From: Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization

Figure 5

Intrathecal application of L-α-AA does not affect microglia activation in Co1 spinal cord of CPCP rats. (A) Low-magnification images of OX42 immunoreactivity in Co1 spinal segments. Scale bar = 200 μm. In the lower images, L-α-AA (150 nmol) was injected intrathecally 5 weeks after cast removal, and this treatment did not affect increased OX42 immunoreactivity. (B) Schematic illustration of Co1. The predefined inside square area including lamina I–IV designates the area of quantitative analysis of OX42 microglia immunoreactivity. (C) The total area of OX42 immunoreactivity in Co1 in intact rats and L-α-AA-treated CPCP rats. *p < 0.05 as compared with the intact group (ANOVA followed by Dunnett’s post hoc test).

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Molecular Pain

ISSN: 1744-8069

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