Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization

Table 1 ATF3 immunoreactivity in DRG at 2-week cast immobilization

	Intact	SNT	CPCP ipsilateral	CPCP contralateral
L3 DRG (n)	―	―	1.64 ± 0.37% n.s. (6)	0.39 ± 0.15% n.s. (6)
L4 DRG (n)	0.33 ± 0.12% (6)	56.78 ± 2.48% # (6)	1.30 ± 0.53% n.s. (5)	0.12 ± 0.08% n.s. (5)
L5 DRG (n)	―	―	0.85 ± 0.16% n.s. (6)	0.65 ± 0.22% n.s. (6)

DRGs were harvested 3 days after SNT, week 2 during cast immobilization. All values are means ± SEM (n = 5–6). #p < 0.05 as compared to the intact value, n.s.: no significance to the intact value (Dunnett’s post hoc test). DRG: dorsal root ganglion; SNT: sciatic nerve transection; CPCP: chronic post-cast pain.

ISSN: 1744-8069