SNI causes delayed opening of the BSCB in CD-1 mice. A longitudinal study using DCE-MRI to follow BSCB permeability over time (hours post-surgery) in SNI (red) and control (blue) treatment groups. Left panel shows the mean data averaged over the thoracic and lumbar ROIs. The error bars represent 90% confidence intervals determined by bootstrap resampling of ROI intensity values at each time point; *p < 0.05 compared to controls. Right panel shows the data fitted with a linear mixed effects model, assuming a constant intensity for control mice and modeling intensity deviations in SNI mice with a natural spline consisting of two internal knot points (after logarithmically scaling time). The mean data points are shown after removal of per subject random effects and the grey shaded regions illustrate 90% confidence intervals determined by bootstrap resampling of subjects.