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Figure 4 | Molecular Pain

Figure 4

From: Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund’s adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats

Figure 4

Formalin induced-depression of intracranial self-stimulation (ICSS) is dose and time related. Abscissa: Days after varying doses of intraplantar formalin or saline administration. Ordinate: ICSS rate expressed as percent baseline stimulations per component. Statistical analysis was performed using two-way Repeated Measures ANOVA followed by the Holm-Sidak post hoc test (p < 0.05). Dollar signs ($) indicate a significant within-group difference from the pre-injection baseline, and filled points indicate a significant between-group difference at that time point relative to saline treatment. All data show mean ± SEM from 6 rats per treatment. See Additional file 1 for detailed statistical results.

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Molecular Pain

ISSN: 1744-8069

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