|
ROIs
|
SNI group (n = 12)
|
Sham group (n = 10)
|
|---|
|
Naïve
|
SNI
|
GBP
|
Naïve
|
Sham
|
GBP
|
|---|
|
mPFC i
|
36.5 ± 2.1
|
35.2 ± 2.0
|
* 29.6 ± 1.1
|
34.6 ± 2.2
|
35.9 ± 1.3
|
31.5 ± 1.6
|
|
mPFC c
|
37.9 ± 1.8
|
35.0 ± 2.0
|
* 29.7 ± 1.2
|
33.1 ± 2.2
|
33.5 ± 1.5
|
28.6 ± 2.0
|
|
ACC i
|
36.9 ± 1.7
|
37.4 ± 2.6
|
* 31.4 ± 1.3
|
37.3 ± 1.8
|
37.9 ± 1.5
|
34.1 ± 2.8
|
|
ACC c
|
34.7 ± 1.4
|
35.6 ± 2.6
|
32.3 ± 1.4
|
34.5 ± 1.8
|
35.8 ± 1.9
|
32.2 ± 2.8
|
|
RSC i
|
20.0 ± 1.7
|
# 14.8 ± 2.4
|
14.5 ± 2.1
|
18.9 ± 1.7
|
15.1 ± 2.3
|
15.4 ± 2.4
|
|
RSC c
|
20.2 ± 1.6
|
# 14.8 ± 2.3
|
13.7 ± 2.2
|
18.8 ± 1.9
|
15.0 ± 2.8
|
15.0 ± 2.8
|
|
IC i
|
1.4 ± 1.5
|
# 4.8 ± 1.4
|
3.6 ± 1.8
|
1.3 ± 2.1
|
0.3 ± 2.1
|
1.6 ± 3.1
|
|
IC c
|
1.3 ± 1.4
|
# 5.1 ± 1.5
|
3.6 ± 1.6
|
1.4 ± 2.0
|
0.5 ± 2.1
|
1.5 ± 3.0
|
|
S1HL i
|
14.7 ± 1.3
|
15.7 ± 1.3
|
15.1 ± 2.0
|
15.3 ± 1.6
|
12.3 ± 1.5
|
13.0 ± 3.1
|
|
S1HL c
|
15.3 ± 1.6
|
15.7 ± 1.6
|
15.2 ± 1.1
|
13.5 ± 2.3
|
12.5 ± 1.6
|
13.0 ± 3.0
|
|
S1BF i
|
18.7 ± 0.9
|
18.0 ± 1.6
|
** 25.0 ± 1.0
|
18.5 ± 1.3
|
18.5 ± 1.1
|
21.5 ± 2.4
|
|
S1BF c
|
18.6 ± 1.0
|
18.7 ± 1.5
|
** 25.7 ± 1.0
|
18.5 ± 1.3
|
17.6 ± 0.8
|
22.6 ± 2.4
|
|
S1ULp i
|
19.4 ± 1.6
|
19.7 ± 1.5
|
*** 27.2 ± 1.2
|
21.8 ± 1.3
|
22.6 ± 1.8
|
25.9 ± 2.0
|
|
S1ULp c
|
17.9 ± 1.5
|
19.3 ± 1.6
|
** 27.1 ± 1.4
|
22.3 ± 2.0
|
21.1 ± 0.9
|
24.0 ± 2.2
|
|
S2
|
9.8 ± 1.9
|
10.4 ± 1.7
|
* 16.4 ± 1.9
|
11.9 ± 1.4
|
10.4 ± 1.8
|
15.2 ± 2.0
|
|
S2
|
10.4 ± 2.2
|
10.8 ± 1.8
|
** 20.1 ± 1.4
|
14.3 ± 1.7
|
10.8 ± 1.3
|
13.6 ± 2.1
|
|
M1 i
|
14.1 ± 2.3
|
15.2 ± 1.5
|
15.5 ± 0.8
|
16.2 ± 1.8
|
15.3 ± 2.0
|
16.7 ± 3.1
|
|
M1 c
|
13.9 ± 2.9
|
13.3 ± 1.8
|
16.1 ± 1.1
|
14.6 ± 1.7
|
15.3 ± 2.1
|
15.2 ± 2.8
|
|
CPu i
|
31.8 ± 1.6
|
28.6 ± 1.9
|
28.6 ± 1.3
|
28.6 ± 1.5
|
28.9 ± 1.4
|
28.7 ± 2.2
|
|
CPu c
|
33.7 ± 1.2
|
28.8 ± 1.9
|
29.7 ± 1.4
|
30.4 ± 1.4
|
28.9 ± 1.5
|
29.5 ± 2.2
|
|
Po i
|
21.4 ± 1.1
|
# 26.2 ± 1.6
|
** 21.0 ± 1.3
|
22.2 ± 1.2
|
23.9 ± 1.2
|
21.8 ± 2.3
|
|
Po c
|
24.5 ± 1.0
|
27.8 ± 1.7
|
** 22.3 ± 1.4
|
23.7 ± 1.2
|
25.0 ± 1.4
|
23.3 ± 2.1
|
|
VP i
|
8.4 ± 1.1
|
## 13.2 ± 1.2
|
9.5 ± 1.1
|
11.1 ± 1.3
|
10.0 ± 1.2
|
8.2 ± 1.8
|
|
VP c
|
9.3 ± 1.0
|
12.3 ± 0.9
|
* 9.2 ± 1.1
|
10.1 ± 1.3
|
11.0 ± 1.2
|
8.5 ± 1.7
|
|
AMY i
|
-9.3 ± 1.2
|
-11.3 ± 1.3
|
* -7.9 ± 1.2
|
-10.9 ± 0.9
|
-13.0 ± 1.4
|
-10.4 ± 0.9
|
|
AMY c
|
-5.3 ± 1.2
|
# -7.0 ± 1.1
|
-5.8 ± 1.4
|
-8.1 ± 0.6
|
-10.0 ± 1.3
|
-9.3 ± 1.0
|
|
Cb vermis
|
4.7 ± 1.7
|
## 12.0 ± 1.2
|
** 6.9 ± 1.2
|
5.2 ± 1.7
|
5.6 ± 1.7
|
7.2 ± 2.0
|
- Post-surgery (SNI) compared to pre-surgery (Naïve) by the one-way repeated measures ANOVA, #P < 0.05, ##P < 0.01. Gabapentin treatment (GBP) compared to post-surgery by the one-way repeated measures ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001. i: ipsilateral; c: contralateral. Data were presented as mean ± SEM. Abbreviations refer to the main text.
