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Figure 2 | Molecular Pain

Figure 2

From: α9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia

Figure 2

Chronic hot/cold hypersensitivity is normal in α9-nAChR KO mice. Thermal hyperalgesia was tested on a 54°C hotplate. Thermal hyperalgesia develops normally in both WT and α9-nAChR KO mice in an inflammatory pain model (A) and is characteristically absent in a neuropathic pain model (B). Cold allodynia is present in both genotypes after CCI and is maintained for at least 3 weeks post-injury (C).

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Molecular Pain

ISSN: 1744-8069

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