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Figure 4 | Molecular Pain

Figure 4

From: α9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia

Figure 4

Chronic mechanical hyperalgesia is reduced in α9-nAChR KO mice. Inflammatory (A) and neuropathic (B) pain models produce chronic mechanical allodynia in both WT and KO animals. However, the magnitude of hyperalgesia is less in α9-nAChR KO animals. α9-nAChR KO animals recover from CCI by 14 days post injury (B i) and are resistant to the repeated-measures induced hyperalgesia of the paw pressure test seen in WT animals (B ii). ##, p < 0.01; ###, p < 0.001; ####, p < 0.0001 compared to baseline. *, p < 0.01; **, p < 0.01; ***, p < 0.001 compared to WT.

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