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Figure 2 | Molecular Pain

Figure 2

From: Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice

Figure 2

Basic synaptic transmission and long-term potentiation in the ACC with NB001 application. (A-B) Two mapped figures showed the LTP of the fEPSP slope was blocked in the presence of NB001 (0.1 μM). The baseline responses (A) were not potentiated 3 h after TBS applied on one channel (yellow lightning bolt) (B). (C) The sample traces and the plotted slope results of two channels (Ch. 27 and Ch. 35) in superficial layer from one slice showed the potentiation of the fEPSP was blocked with NB001 application. (D) The plotted slope from 9 channels in superficial layer was not potentiated with NB001 application. (E) The sample traces and the plotted slope results of two channels (Ch. 29 and Ch. 36) in deep layer from the same slice showed the potentiation of the fEPSP were both blocked with NB001 application. (F) The plotted slope from 13 channels in deep layer was not potentiated with NB001 application. (G) The summarized fEPSP slopes of 6 slices/6 mice showed that NB001 application blocked the L-LTP induction. (H) The summarized fEPSP slopes of 6 slices/6 mice showed that NB001 application did not change the basal synaptic transmission.

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Molecular Pain

ISSN: 1744-8069

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