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Figure 6 | Molecular Pain

Figure 6

From: Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice

Figure 6

Effect of gabapentin and NB001 on the LTP and basal synaptic transmission. (A) Diagram of one ACC slice showing the placement of the whole cell patching system: stimulation electrode was placed on layer V and pyramidal cells in layer II/III were recorded. (B) The superimposed sample traces and the averaged results showed that spiking timing protocol could induce LTP lasted for 30 min in pyramidal neurons. (C-D) Spike timing protocol induced LTP was blocked in the presence of NB001 (0.1 μM, C) but not gabapentin (100 μM, D). (E) The summarized results of B-D were plotted. (F) Basal synaptic transmission was stable in control slice. (G-H) The basal synaptic transmission was not affected by NB001 (G) but reduced by gabapentin application (H). (I) The summarized results of F-H were plotted.

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Molecular Pain

ISSN: 1744-8069

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