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Figure 8 | Molecular Pain

Figure 8

From: Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice

Figure 8

A Model explains synaptic mechanisms of NB001 and gabapentin in the ACC. (A) A synaptic model showing AC1 acts downstream from the glutamate NMDA receptors and activated in a calcium-dependent manner. NB001 inhibited the AC1 as a drug target for blocking the LTP in the ACC. (B) Gabapentin may have inhibitory effect on the AMPAR mediated synaptic transmission.

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Molecular Pain

ISSN: 1744-8069

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