Figure 2

Chronic pancreatitis pathology with fibrosis and LY3038404 HCl effectively reduced pancreatic tissue fibrosis. Representative bright field images of Sirius red stained pancreatic sections. A. Normal chow control group had little fibrosis. B. AHF pancreatitis group rats had an invasive fibrous network around the acini, blood vessels, and ducts. C. LY3038404 HCl treated rats with AHF pancreatitis showed an improvement with much less tissue fibrosis. D. The histogram shows the statistically significant increase in percent fibrosis relative to total tissue area in AHF fed rats with chronic pancreatitis compared to the controls (n = 6/group, **p < 0.01 and ***p < 0.001). LY3038404 HCl treatment effectively protected rats with AHF pancreatitis from severe pancreatic tissue damage (n = 6/group, ^## p < 0.01 and ^### p < 0.001).