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Figure 5 | Molecular Pain

Figure 5

From: Cannabinoid receptor 2 agonist attenuates pain related behavior in rats with chronic alcohol/high fat diet induced pancreatitis

Figure 5

LY3038404 HCl attenuated evoked pain related behaviors. LY3038404 HCl (10 mg/kg, oral, twice a day, 7 days), effectively attenuated pain related behaviors. A. Secondary paw mechanical allodynia was reduced (AHF vs. AHF + LY3038404 HCl, n = 6/group, Two-way ANOVA, Bonferroni post-test, *p < 0.05; **p < 0.01; ***p < 0.001). B. Secondary abdominal heat hyperalgesia was reduced (AHF vs. AHF + LY3038404 HCl, Two-way ANOVA, Bonferroni post-test, n = 6/group *p < 0.05, **p < 0.01, ***p < 0.001). C. LY3038404 HCl (10 mg/kg, twice daily, 8 days) reduced hypersensitivity to noxious 44°C hindpaw stimulation (10 min). LY3038404 HCl prolonged the first response latency and reduced the cumulative amount of hind-paw lick or guard reflex events. Compared to rats without drug treatment, the event and time curve of drug treatment group showed a right-ward shift.

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