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Figure 6 | Molecular Pain

Figure 6

From: Cannabinoid receptor 2 agonist attenuates pain related behavior in rats with chronic alcohol/high fat diet induced pancreatitis

Figure 6

LY3038404 HCl did not affect light/dark box preference. A. Rats with AHF pancreatitis spent more time in the light compartment (300.77±36.45 s) than did rats fed regular chow (148.97±15.7 s) (t-test, *p < 0.05). B. The number of transitions between the light and dark compartments was increased in rats with AHF pancreatitis (6±0.66/10 min) compared to normal chow controls (4±0.57/10 min, t-test, *p < 0.05). C. LY3038404 HCl (10 mg/kg, oral feeding, twice daily, for 9 days) did not affect the light/dark preference behaviors of AHF pancreatitis rats. The time spent in the light compartment for rats with AHF pancreatitis without drug treatment (287.1±6 s) was similar to that of the drug treatment group (275.4±22.3 s) (One-way ANOVA, *p < 0.05). D. The number of transitions between the light and dark compartments for rats with AHF pancreatitis (7.33±0.85/10 min) was significantly greater than control chow fed rats (3.2 ± 0.6/10 min, *p < 0.05), but there was no effect with drug treatment (7.67±0.61/10 min) (Chow vs. AHF, AHF vs. AHF + LY3038404 HCl, One-way ANOVA, Tukey's Multiple Comparison test, n = 6/group, p > 0.05).

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