Figure 2

Intradermal injection of SB366791 partially attenuated thermal hyperalgesia induced by plantar incision. (A) Intradermal injection of vehicle 30 min before and immediately after the plantar incision did not affect thermal hyperalgesia measured as a significant decrease of PWL in the incised hind paw (n = 6). Intradermal injection of 100 μM SB366791 (30 min before and immediately after the surgery) had a significant analgesic effect on the postoperative thermal hyperalgesia (n = 8). (B) Intradermal injection of vehicle (n = 6) or 100 μM SB366791 (n = 4) 30 min before and immediately after the sham surgery did not affect the basal thermal sensitivity. **P <0.01, ***P <0.001 SB366791 injection: ipsilateral versus contralateral side; ⁺⁺P <0.01, ⁺⁺⁺P <0.001 vehicle injection: ipsilateral versus contralateral side; ^#P <0.05, ^##P <0.01, ^###P <0.001 SB366791 versus vehicle injection on the ipsilateral hind paw. The time of drug administration is marked by arrow.