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Figure 2 | Molecular Pain

Figure 2

From: Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8

Figure 2

Enhanced behavioral responses to cold stimuli in CGRPα sensory neuron-ablated mice is dependent on TRPM8. Saline- and DTX-treated Cgrpα-DTR+/- and DTR-Trpm8-/- mice were tested in the (A) -10°C tail withdrawal assay, (B) acetone-(50 μl) evoked evaporative cooling assay, (C) cold plantar assay, and (D) after injecting icilin (2.4 μg/μl) into the hindpaw. The number of flinches that occurred over 10 min was measured. (A-D) t-tests were used to compare pre-saline/DTX and post-saline/DTX-treated mice. All values represent mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.0005. In (B), all TRPM8-/- mice showed significantly less time licking hindpaw in the acetone-evoked evaporative cooling assay compared to WT controls (p < 0.0005).

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