Skip to main content
Figure 3 | Molecular Pain

Figure 3

From: Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8

Figure 3

Ablation of CGRPα sensory neurons in DTR-Trpm8-/- mice reduces heat sensitivity but does not enhance cold sensitivity. Sensitivity to temperatures ranging from noxious hot to noxious cold was measured using the hindpaw withdrawal assay. (A) Cgrpα-DTR+/- and (B) DTR-Trpm8-/- mice pre- and post-saline/DTX treatment. All values are represented as mean ± SEM. Cutoff time was 30 s. Animals that did not withdraw their paw by this cutoff time were assigned a cutoff time of 30 s. t-tests were used to compare time points between pre-saline/DTX and post-saline/DTX-treated mice. *p < 0.05, **p < 0.005, ***p < 0005.

Back to article page