Figure 5

Absence of paclitaxel-induced mechanical allodynia in LPA ₁ and LPA ₃ knockout mice. Time course of mechanical paw withdrawal latencies (PWT, in g) after intraperitoneal injections of paclitaxel on 4 alternate days (day 0, 2, 4, and 6) in wild-type (WT), Lpar1^−/−, and Lpar3^−/− mice. Mechanical pain thresholds were evaluated by using mechanical paw withdrawal test. Data represent means ± SEM from experiments using 4–6 mice. *p < 0.05, versus vehicle-treated WT mice; ^# p < 0.05, versus paclitaxel-treated WT mice.