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Figure 1 | Molecular Pain

Figure 1

From: Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons

Figure 1

S1P potentiates capsaicin-induced currents in cultured DRG sensory neurons. A, a typical voltage-clamp recording from a DRG neuron that is repetitively stimulated with capsaicin (0.3 μM white and grey triangles). Between the 3rd and 4th capsaicin application DRG neurons were stimulated with 1.0 μM S1P (green bar) that resulted in augmentation of ICAPS (grey triangles). The dashed line represents 0 nA. B, Quantification of S1P induced potentiation of ICAPS, which were normalized to amplitude of the 3rd ICAPS, showed that S1P potently increased ICAPS up to 4 minutes after S1P application. ***p < 0.001, *p < 0.05, MWU-test. C, Repetitive application of capsaicin did not result in potentiation of ICAPS. Numbers within the bars represent the number of individual recorded.

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Molecular Pain

ISSN: 1744-8069

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