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Figure 3 | Molecular Pain

Figure 3

From: Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons

Figure 3

I CAPS sensitization by depends on S1P 1 receptor signaling. A, The enhancement of ICAPS by the S1P1 specific receptor agonist SEW2871 (1.0 μM) was completely inhibited by pertussis toxin (PTX, 100 ng/ml). The dashed line signifies the zero current. B, Moreover, inhibition of the PI3K by Wortmannin (WM, 1.0 μM) and PKC (BIM-1, 1.0 μM) fully prevented the potentiation of ICAPS that was induced by S1P1 receptor activation by SEW2781 (SEW). *p < 0.05, MWU-test, numbers within the bars represent the number of individual cells recorded.

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