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Table 1 Allelic frequencies of SNPs in five LD blocks around the P2RX7 gene of Japanese subjects

From: Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl

rs number of SNPs Position   Major allele Minor allele Frequency LD block
rs12819523 Flanking_5UTR -45261 G A 7.5%  
rs12819930 Flanking_5UTR -45087 G A 10.7% 1
rs10492051 Flanking_5UTR -45012 G - 0.0%  
*rs2708092 Flanking_5UTR -44792 A G 49.0% 1
*rs1180012 Flanking_5UTR -40230 C T 38.8% 1
rs2516210 Flanking_5UTR -35256 T C 15.9% 1
rs1796421 Flanking_5UTR -30332 T C 15.9% 1
rs1796412 Flanking_5UTR -28966 T C 18.2% 1
rs7298521 Flanking_5UTR -28847 C T 22.9% 1
rs1794899 Flanking_5UTR -27705 G A 18.0% 1
rs1796415 Flanking_5UTR -27667 T - 0.0%  
rs3892756 Flanking_5UTR -16010 T - 0.0%  
rs10849846 Flanking_5UTR -12255 T C 21.8% 1
rs208277 Flanking_5UTR -10097 A G 41.1% 1
rs12314721 Flanking_5UTR -4921 C T 14.9% 1
rs9805004 Flanking_5UTR -4808 C T 18.2% 1
rs670541 Flanking_5UTR -1044 C T 8.9% 1
rs591874 Intron1 IVS1 + 567 A C 40.9% 1
rs7959194 Intron1 IVS1 + 5089 G - 0.0%  
rs11065450 Intron1 IVS1 + 8759 C A 28.7%  
rs568531 Intron1 IVS1 + 8775 C T 7.5% 2
rs607094 Intron1 IVS1 + 9566 T C 6.4% 2
rs208286 Intron1 IVS1-5688 G - 0.0%  
rs17525809 Exon2 T227C[V76A] T C 8.9%  
*rs1718125 Intron2 IVS2 + 263 G A 28.3% 3
rs10849851 Intron3 IVS3-2061 A G 21.0% 3
rs1653583 Intron3 IVS3-53 C T 7.2% 3
*rs208293 Intron4 IVS4-47 G A 41.1% 3
rs208294 Exon5 T463C[Y155H] T C 43.5% 3
rs1186055 Intron5 IVS5 + 206 G T 39.5%  
rs208296 Intron5 IVS5 + 630 C T 36.1%  
rs11065464 Intron5 IVS5-1025 C A 24.3%  
rs208298 Intron5 IVS5-922 G A 16.6% 4
rs654856 Intron5 IVS5-38 C A 13.4% 4
rs2857589 Intron7 IVS7 + 486 C A 5.1% 4
rs503720 Intron7 IVS7-217 G A 16.1% 4
rs16950860 Exon8 C808T[R270C] C - 0.0%  
rs7958311 Exon8 G809A[R270H] G A 35.6%  
rs7958316 Exon8 G827A[R276H] G - 0.0%  
*rs1718136 Intron8 IVS8-3583 A G 15.0% 5
rs7137542 Intron8 IVS8-545 G - 0.0%  
*rs7132846 Intron9 IVS9-16 C T 12.9% 5
rs1718119 Exon11 G1040A[A348T] G A 17.5% 5
rs1653598 Intron11 IVS11 + 34 A G 14.9% 5
rs2567998 Intron11 IVS11-16 A - 0.0%  
rs10160951 Exon12 C1289G[P430R] C - 0.0%  
rs12829218 Intron12 IVS12 + 133 A - 0.0%  
rs891781 Intron12 IVS12 + 180 C T 17.5% 5
rs7312642 Intron12 IVS12-1921 G T 12.1%  
rs12815078 Intron12 IVS12-101 A G 6.1%  
rs2230912 Exon13 A1379G[Q460R] A - 0.0%  
rs3751144 Exon13 C1422T C T 12.9%  
rs3751143 Exon13 A1487C[E496A] A C 32.0%  
rs1718161 Flanking_3UTR +3582 A G 6.5%  
rs2686365 Flanking_3UTR +9907 C - 0.0%  
  1. *Tag SNPs in the LD blocks (selected using Tagger software with default settings; r2 > 0.8).