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Table 3 Patients’ demographic and clinical data

From: Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl

  rs2708092 rs1180012 rs1718125
  AA AG + GG CC CT + TT GG GA + AA
Age (years) 26.1 ± 7.0 25.8 ± 7.8 27.3 ± 7.7 25.1 ± 7.5 26.6 ± 7.7 25.2 ± 7.5
Male/Female 32/67 92/163 51/77 74/153 65/115 60/115
PPLpre (s) 15 [10,21] 14 [9,23] 14 [9,23] 14 [9, 23] 14 [9, 22] 15 [9, 23]
PPLpost (s) 29 [18, 52] 27 [16, 54] 28 [16, 49] 28 [16, 54] 27 [16, 49] 30 [16, 56]
Analgesic effect (PPLpost-PPLpre) (s) 15 [5, 35] 11 [4, 35] 10 [4, 30] 13 [4, 36] 10 [4, 30] 14 [5, 37]
24-h postoperative fentanyl use (μg/kg) 2.2 [1.2, 4.7] 2.3 [1.0, 4.1] 2.3 [0.9, 4.1] 2.3 [1.1, 4.3] 2.1 [0.9, 3.9] 2.4 [1.3, 4.4]
Perioperative fentanyl use (μg/kg) 7.6 [5.8, 9.2] 6.7 [5.1, 9.1] 6.8 [5.0, 9.1] 7.1 [5.3, 9.1] 6.8 [5.0, 8.6] 7.1 [5.5, 9.5]
Total perioperative analgesic use (μg/kg) 8.5 [6.7, 10.2] 7.6 [6.0, 10.1] 7.7 [5.8, 10.2] 8.0 [6.2, 10.0] 7.8 [5.8, 9.6] 8.0 [6.3, 10.5]
VAS pain score at 3 h (mm) 27 [15, 47] 27 [15, 50] 27 [15, 50] 30 [15, 50] 27 [15, 50] 30 [16, 50]
VAS pain score at 24 h (mm) 25 [10, 38] 25 [10, 45] 22 [8, 40] 26 [11, 43] 23 [8, 40] 28 [14, 46]*
  rs208293 rs1718136 rs7132846
  GG GA + AA AA AG + GG CC CT + TT
Age (years) 27.5 ± 7.9 25.2 ± 7.4 26.2 ± 7.9 25.4 ± 6.9 25.7 ± 7.3 26.8 ± 8.8
Male/Female 41/70 84/160 95/152 30/78 104/170 21/60
PPLpre (s) 13 [9, 22] 15 [9, 24] 14 [9, 24] 15 [9, 21] 14 [9, 23] 14 [9, 23]
PPLpost (s) 27 [16, 51] 28 [16, 54] 29 [16, 56] 25 [15, 48] 28 [16, 53] 28 [16, 53]
Analgesic effect (PPLpost-PPLpre) (s) 10 [3, 34] 13 [5, 35] 13 [5, 36] 11 [4, 30] 12 [4, 35] 12 [4, 35]
24-h postoperative fentanyl use (μg/kg) 2.3 [1.1, 4.0] 2.3 [1.0, 4.3] 2.3 [1.1, 4.3] 2.0 [1.0, 4.1] 2.3 [1.1, 4.2] 2.3 [1.0, 4.2]
Perioperative fentanyl use (μg/kg) 6.8 [5.1, 9.0] 7.1 [5.3, 9.2] 7.0 [5.2, 9.2] 6.7 [5.2, 8.9] 6.9 [5.2, 9.1] 6.9 [5.2, 9.1]
Total perioperative analgesic use (μg/kg) 7.7 [5.9, 10.1] 8.0 [6.2, 10.1] 8.0 [6.1, 10.1] 7.7 [6.1, 9.9] 8.0 [6.1, 10.1] 8.0 [6.1, 10.1]
VAS pain score at 3 h (mm) 27 [16, 50] 27 [15, 49] 27 [15, 50] 26 [15, 49] 28 [15, 50] 27 [15, 50]
VAS pain score at 24 h (mm) 22 [10, 39] 26 [11, 45] 25 [10, 42] 25 [8, 42] 25 [10, 42] 25 [10, 42]
  1. The data are expressed as numbers, mean ± SD (range), or median [interquartile range]. *p <0.05, compared with subjects not carrying minor allele.