| rs2708092 | rs1180012 | rs1718125 | |||
---|---|---|---|---|---|---|
 | AA | AG + GG | CC | CT + TT | GG | GA + AA |
Age (years) | 26.1 ± 7.0 | 25.8 ± 7.8 | 27.3 ± 7.7 | 25.1 ± 7.5 | 26.6 ± 7.7 | 25.2 ± 7.5 |
Male/Female | 32/67 | 92/163 | 51/77 | 74/153 | 65/115 | 60/115 |
PPLpre (s) | 15 [10,21] | 14 [9,23] | 14 [9,23] | 14 [9, 23] | 14 [9, 22] | 15 [9, 23] |
PPLpost (s) | 29 [18, 52] | 27 [16, 54] | 28 [16, 49] | 28 [16, 54] | 27 [16, 49] | 30 [16, 56] |
Analgesic effect (PPLpost-PPLpre) (s) | 15 [5, 35] | 11 [4, 35] | 10 [4, 30] | 13 [4, 36] | 10 [4, 30] | 14 [5, 37] |
24-h postoperative fentanyl use (μg/kg) | 2.2 [1.2, 4.7] | 2.3 [1.0, 4.1] | 2.3 [0.9, 4.1] | 2.3 [1.1, 4.3] | 2.1 [0.9, 3.9] | 2.4 [1.3, 4.4] |
Perioperative fentanyl use (μg/kg) | 7.6 [5.8, 9.2] | 6.7 [5.1, 9.1] | 6.8 [5.0, 9.1] | 7.1 [5.3, 9.1] | 6.8 [5.0, 8.6] | 7.1 [5.5, 9.5] |
Total perioperative analgesic use (μg/kg) | 8.5 [6.7, 10.2] | 7.6 [6.0, 10.1] | 7.7 [5.8, 10.2] | 8.0 [6.2, 10.0] | 7.8 [5.8, 9.6] | 8.0 [6.3, 10.5] |
VAS pain score at 3Â h (mm) | 27 [15, 47] | 27 [15, 50] | 27 [15, 50] | 30 [15, 50] | 27 [15, 50] | 30 [16, 50] |
VAS pain score at 24Â h (mm) | 25 [10, 38] | 25 [10, 45] | 22 [8, 40] | 26 [11, 43] | 23 [8, 40] | 28 [14, 46]* |
 | rs208293 | rs1718136 | rs7132846 | |||
 | GG | GA + AA | AA | AG + GG | CC | CT + TT |
Age (years) | 27.5 ± 7.9 | 25.2 ± 7.4 | 26.2 ± 7.9 | 25.4 ± 6.9 | 25.7 ± 7.3 | 26.8 ± 8.8 |
Male/Female | 41/70 | 84/160 | 95/152 | 30/78 | 104/170 | 21/60 |
PPLpre (s) | 13 [9, 22] | 15 [9, 24] | 14 [9, 24] | 15 [9, 21] | 14 [9, 23] | 14 [9, 23] |
PPLpost (s) | 27 [16, 51] | 28 [16, 54] | 29 [16, 56] | 25 [15, 48] | 28 [16, 53] | 28 [16, 53] |
Analgesic effect (PPLpost-PPLpre) (s) | 10 [3, 34] | 13 [5, 35] | 13 [5, 36] | 11 [4, 30] | 12 [4, 35] | 12 [4, 35] |
24-h postoperative fentanyl use (μg/kg) | 2.3 [1.1, 4.0] | 2.3 [1.0, 4.3] | 2.3 [1.1, 4.3] | 2.0 [1.0, 4.1] | 2.3 [1.1, 4.2] | 2.3 [1.0, 4.2] |
Perioperative fentanyl use (μg/kg) | 6.8 [5.1, 9.0] | 7.1 [5.3, 9.2] | 7.0 [5.2, 9.2] | 6.7 [5.2, 8.9] | 6.9 [5.2, 9.1] | 6.9 [5.2, 9.1] |
Total perioperative analgesic use (μg/kg) | 7.7 [5.9, 10.1] | 8.0 [6.2, 10.1] | 8.0 [6.1, 10.1] | 7.7 [6.1, 9.9] | 8.0 [6.1, 10.1] | 8.0 [6.1, 10.1] |
VAS pain score at 3Â h (mm) | 27 [16, 50] | 27 [15, 49] | 27 [15, 50] | 26 [15, 49] | 28 [15, 50] | 27 [15, 50] |
VAS pain score at 24Â h (mm) | 22 [10, 39] | 26 [11, 45] | 25 [10, 42] | 25 [8, 42] | 25 [10, 42] | 25 [10, 42] |