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Table 3 Patients’ demographic and clinical data

From: Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl

 

rs2708092

rs1180012

rs1718125

 

AA

AG + GG

CC

CT + TT

GG

GA + AA

Age (years)

26.1 ± 7.0

25.8 ± 7.8

27.3 ± 7.7

25.1 ± 7.5

26.6 ± 7.7

25.2 ± 7.5

Male/Female

32/67

92/163

51/77

74/153

65/115

60/115

PPLpre (s)

15 [10,21]

14 [9,23]

14 [9,23]

14 [9, 23]

14 [9, 22]

15 [9, 23]

PPLpost (s)

29 [18, 52]

27 [16, 54]

28 [16, 49]

28 [16, 54]

27 [16, 49]

30 [16, 56]

Analgesic effect (PPLpost-PPLpre) (s)

15 [5, 35]

11 [4, 35]

10 [4, 30]

13 [4, 36]

10 [4, 30]

14 [5, 37]

24-h postoperative fentanyl use (μg/kg)

2.2 [1.2, 4.7]

2.3 [1.0, 4.1]

2.3 [0.9, 4.1]

2.3 [1.1, 4.3]

2.1 [0.9, 3.9]

2.4 [1.3, 4.4]

Perioperative fentanyl use (μg/kg)

7.6 [5.8, 9.2]

6.7 [5.1, 9.1]

6.8 [5.0, 9.1]

7.1 [5.3, 9.1]

6.8 [5.0, 8.6]

7.1 [5.5, 9.5]

Total perioperative analgesic use (μg/kg)

8.5 [6.7, 10.2]

7.6 [6.0, 10.1]

7.7 [5.8, 10.2]

8.0 [6.2, 10.0]

7.8 [5.8, 9.6]

8.0 [6.3, 10.5]

VAS pain score at 3 h (mm)

27 [15, 47]

27 [15, 50]

27 [15, 50]

30 [15, 50]

27 [15, 50]

30 [16, 50]

VAS pain score at 24 h (mm)

25 [10, 38]

25 [10, 45]

22 [8, 40]

26 [11, 43]

23 [8, 40]

28 [14, 46]*

 

rs208293

rs1718136

rs7132846

 

GG

GA + AA

AA

AG + GG

CC

CT + TT

Age (years)

27.5 ± 7.9

25.2 ± 7.4

26.2 ± 7.9

25.4 ± 6.9

25.7 ± 7.3

26.8 ± 8.8

Male/Female

41/70

84/160

95/152

30/78

104/170

21/60

PPLpre (s)

13 [9, 22]

15 [9, 24]

14 [9, 24]

15 [9, 21]

14 [9, 23]

14 [9, 23]

PPLpost (s)

27 [16, 51]

28 [16, 54]

29 [16, 56]

25 [15, 48]

28 [16, 53]

28 [16, 53]

Analgesic effect (PPLpost-PPLpre) (s)

10 [3, 34]

13 [5, 35]

13 [5, 36]

11 [4, 30]

12 [4, 35]

12 [4, 35]

24-h postoperative fentanyl use (μg/kg)

2.3 [1.1, 4.0]

2.3 [1.0, 4.3]

2.3 [1.1, 4.3]

2.0 [1.0, 4.1]

2.3 [1.1, 4.2]

2.3 [1.0, 4.2]

Perioperative fentanyl use (μg/kg)

6.8 [5.1, 9.0]

7.1 [5.3, 9.2]

7.0 [5.2, 9.2]

6.7 [5.2, 8.9]

6.9 [5.2, 9.1]

6.9 [5.2, 9.1]

Total perioperative analgesic use (μg/kg)

7.7 [5.9, 10.1]

8.0 [6.2, 10.1]

8.0 [6.1, 10.1]

7.7 [6.1, 9.9]

8.0 [6.1, 10.1]

8.0 [6.1, 10.1]

VAS pain score at 3 h (mm)

27 [16, 50]

27 [15, 49]

27 [15, 50]

26 [15, 49]

28 [15, 50]

27 [15, 50]

VAS pain score at 24 h (mm)

22 [10, 39]

26 [11, 45]

25 [10, 42]

25 [8, 42]

25 [10, 42]

25 [10, 42]

  1. The data are expressed as numbers, mean ± SD (range), or median [interquartile range]. *p <0.05, compared with subjects not carrying minor allele.