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Figure 5 | Molecular Pain

Figure 5

From: NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors

Figure 5

Time-dependent effect (A) and bar representation (B) of NMP-7 delivered intraperitoneally to Ca V 3.2-null mice on inflammatory pain. Each point (Panel A) represents the time dependent mean ± SEM of mechanical withdrawal thresholds of 7–14 wild type or CaV3.2 null mice. Bars (Panel B) represent mean ± SEM responses of mechanical withdrawal threshold measurements taken 30 minutes after i.p. treatment of wild type and CaV3.2 null mice with vehicle (PBS +5% DMSO, black bars) or NMP-7 (white bars) (n = 7-14). Asterisks indicate significance relative to vehicle control group, ***p < 0.001, ns = non significant (Three-way ANOVA for panel A and Two-way ANOVA for panel B, followed by a Tukey’s test).

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Molecular Pain

ISSN: 1744-8069

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