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Figure 4 | Molecular Pain

Figure 4

From: Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons

Figure 4

In vitro expression and current of Kv1.2 in HEK-293 cells transfected with Kv1.2 vector. (A) Representative Western blot showing Kv1.2 expression at the expected size in HEK-293 cells transfected with full-length Kv1.2 vector. β-actin was used as a loading control. (B) Representative traces of Kv1.2 current recorded by whole-cell voltage patch clamp in HEK-293 cells transfected with full-length Kv1.2 vector before or after bath perfusion of 100 nM maurotoxin (MTX). (C) Current–voltage curves of HEK-293 cells transfected with full-length Kv1.2 before or after treatment with 100 nM MTX. The current density was plotted against each step testing voltage. n = 5 cells.

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