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Figure 7 | Molecular Pain

Figure 7

From: Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons

Figure 7

Overexpressing Kv1.2 rescues SNL-induced Kv1.2 downregulation and blocks SNL-induced Kv1.2 AS RNA upregulation in the injured DRG. (A) Quantitative RT-PCR shows Kv1.2 AS RNA, Kv1.2 mRNA, and Kv1.4 mRNA expression in the ipsilateral and contralateral L5 DRGs on day 14 after spinal nerve ligation (SNL) or sham surgery in the AAV5-EGFP-injected and AAV5-Kv1.2-injected groups. n = 12 rats/group. **P < 0.01 vs. the corresponding AAV5-EGFP-injected group after sham surgery; ##P < 0.01 vs. the corresponding AAV5-EGFP-injected group after SNL. (B) Western blot analysis shows Kv1.2 and Kv1.4 protein expression in the ipsilateral (Ipsi) and contralateral (Con) L5 DRGs on day 14 after SNL in the AAV5-EGFP-injected and AAV5-Kv1.2-injected groups. n = 8 rats/group. **P < 0.01 vs. the contralateral side of the AAV5-EGFP-injected group; #P < 0.05 vs. the ipsilateral side of the AAV5-EGFP-injected group. (C) Western blot analysis shows Kv1.2 and Kv1.4 protein expression in the ipsilateral and contralateral L5 DRGs on day 14 after sham surgery in the AAV5-EGFP-injected and AAV5-Kv1.2-injected groups. n = 8 rats/group. **P < 0.01 vs. the contralateral side of the AAV5-EGFP-injected group.

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