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Figure 6 | Molecular Pain

Figure 6

From: Upregulation of cystathionine-β-synthetase expression contributes to inflammatory pain in rat temporomandibular joint

Figure 6

CBS inhibitor AOAA reduces the H 2 S level and reverses neuronal hyperexcitability. (A) Administration of AOAA (i.p., 9 mg/kg three times daily for consecutive 2 days) drastically reduced the level of H2S in TGs when compared with CFA rats (n = 9 rats for each group). (B) Administration of AOAA markedly hyperpolarized RP (CFA + AOAA, n = 20, CFA + NS, n = 20, *p < 0.05, compared with NS, two sample t-Test). (C) AOAA treatment significantly increased rheobase (CFA + AOAA, n = 20; NS, n = 20, * p < 0.05, compared with NS, Mann-Whitney test). (D, E) AOAA treatment also greatly reduced numbers of AP evoked by 2X (left) and 3X (right) rheobase current stimulation (CFA + AOAA, n = 20, CFA + NS, n = 20, *p < 0.05, **p < 0.01, Mann-Whitney test, two sample t-Test).

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