Figure 7

CBS inhibitor AOAA reduces the number of action potentials evoked by ramp current stimulation. (A) Examples of APs by 300 pA (left) and 500 pA (right) current stimulation from NS (top) and AOAA (bottom) treated rats. (B) Bar graph showed a significant decrease in numbers of APs evoked by 300 pA and 500 pA ramp stimulation in AOAA-treated rats (CFA + AOAA, n = 20, CFA + NS, n = 20, **p <0.01, compared with NS, Mann-Whitney test, two sample t-Test). (C) Bar graph representing the mean time to first spike (TTFS) in response to a 300 pA (left) or 500 pA (right) ramp current injection from NS or AOAA-treated rats (*p < 0.05, compared with NS, Mann-Whitney test). (D) Mean interspike interval (ISI) in a spike train of TMJ neurons responding to a 300 pA ramp current stimulation from NS- or AOAA-treated rats (*p < 0.05 compared with NS, Mann-Whitney test). (E) Mean ISI in a spike train of TMJ neurons responding to a 500 pA ramp current stimulation from NS- or AOAA-treated rats (*p < 0.05 compared with NS, Mann-Whitney test).