Figure 1
From: Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors
PKCδ -KO and WT scratching responses to pruritogens. A. PKCδ-KO mice scratched less than wild type littermates in response to intradermal histamine injection (WT = 121.4 ± 12.8 scratch bouts/30 min, n = 25; KO = 73.8 ± 15.5 scratch bouts/30 min, n = 19; unpaired t test p < 0.05). B. Chloroquine (CQ)-induced scratching was not different between PKCδ-KO and WT mice (WT = 163.7 ± 22.6 scratch bouts/30 min, n = 23; KO = 118.0 ± 18.9 scratch bouts/30 min, n = 21; unpaired t test p = 0.129). C. Scratch bouts induced by β-alanine were also not different between PKCδ-KO and WT mice (WT = 57.0 ± 10 scratch bouts/30 min, n = 6; KO = 48.8 ± 12.3 scratch bouts/30 min, n = 8; unpaired t test p = 0.61).