Figure 6

Behavioral outcome of early and late injection of lentiviral constructs. Tactile allodynia in the von Frey test (A), cold allodynia in the acetone test (B), thermal hyperalgesia in the plantar test (C) and mechanical hyperalgesia in the Randall-Selitto test (D) in SCI rats after viral injection encoding endomorphins + SHG injected at early (two weeks, n = 10) or late (6 weeks, n = 12) time points after SCI. Values are expressed as the ± S.E.M. There were no statistical differences observed between early and late SHG-EM injections comparing the data up to 7 weeks post injection, with the exception of week 5, when the threshold for mechanical allodynia was significantly higher in the group injected early post SCI. *p < 0.05.