Figure 3
From: Spinal autophagy is differently modulated in distinct mouse models of neuropathic pain
Densitometric analysis of autophagic markers changes detected by Western blot in the spinal dorsal horn following three different models of peripheral nerve injury (SNL, SNI and CCI). The SNL model (A) was characterised by increased LC3-II and p62, whereas in the SNI (B) and CCI (C) only LC3-II and Beclin 1 increase were detected, respectively. A statistically significant upregulation of the voltage-gated calcium channel subunit α2δ-1 was observed in the injured side of the SNL and the SNI model. Signals from each band were normalised towards the corresponding GAPDH signal. Values were expressed as mean ± SEM. *P < 0.05, SNL n = 8, SNI n = 5, CCI n = 5.