Inhibition of HVA I
by zolmitriptan. (a) Typical illustration of IBa elicited in response to command pulses from -60 mV to 10 mV for 40 ms. IBa was inhibited by 2 min application of 10 μM zolmitriptan. (b) The average time course of IBa inhibition by zolmitriptan at four different concentrations. Superfusing application of zolmitriptan started at t = 0 and lasted for 120 s during the period indicated by horizontal bar. Mean value of the relative amplitude of IBa compared to the control IBa at t = 0 was plotted on ordinate (IBa ratio) against time on abscissa. The number of neurons examined is indicated for the respective concentrations. S.E.M. value was not indicated. (c) Concentration-inhibition relationship for zolmitriptan. Bar graph shows the relative amplitude of IBa at two minutes after application of zolmitriptan compared to the control. (*p < 0.05 **p < 0.01).