Moderate hypoxia effects outward currents differently. A, B) Current recordings (holding potential -80 mV, step to +40 mV) of neurones showing either decreased (A) or increased (B) whole-cell outward currents in hypoxic Ringer's solution. C, D) Current-voltage relation of neurones with reduced outward currents (C, 77% of neurones) or increased outward currents (D, 23% of neurones) in hypoxia. The insets show the I-V relation for the difference currents between control and hypoxia (C). Data represent mean ± S.E.M., pipette: High-Ki EGTA, n = 23.