A clinical genetic method to identify mechanisms by which pain causes depression and anxiety

Molecular Pain

Table 1 Contributions of the variables to baseline SF-36 Mental Health scores

			Correlation (r) with
Quantitative variables	Mean	STD	Baseline SF36-MH		R²	p-value
Baseline bodily pain	3.67	1.12	-0.36		0.130	<0.0001
Age	41.8	10.6	0.15		0.023	0.0121
			Baseline SF36-MH
Categorical variables	Category	n	Mean	STD
Sex	Male	166	61.25	19.88	0.002	0.5065
	Female	110	62.95	19.35
Workers' compensation	Yes	105	56.15	20.53	0.052	0.0001
	No	171	65.47	18.27
Length of episode	<=6 week	54	68.52	18.99	0.033	0.0109
	6–26 weeks	133	61.29	17.95
	>26 weeks	89	58.88	21.68	0.006	0.2024
Comorbid illnesses	Yes	69	59.36	19.81
	No	207	62.78	19.58
	R² from the model including all above variables				0.227

Note: R² was calculated using the model including only one variable.
SF-36 MH scores range from 0–100, where 100 means "always happy and calm over past month."
280 (surgical+ non-surgical) patients have DNA, four patients, 3 missing baseline SF36-MH and 1 missing baseline bodily pain, were dropped from analysis
In covariate selection, linear regression with backward selection method (p = 0.1) was applied, where baseline Sf36-MH was dependent variables, age, sex, workers' compensation, baseline bodily pain, comorbid illnesses, patient group (nonsurgical vs. surgical), marital status, education, and prior episodes were independent variables, and age, sex and workers' compensation were fixed in the model

ISSN: 1744-8069