A clinical genetic method to identify mechanisms by which pain causes depression and anxiety

Molecular Pain

Table 2 Contributions of the variables to 1-year SF-36 Mental Health scores

			Correlation (r) with
Quantitative variables	Mean	STD	1 year SF36-MH		R²	p-value
Mean bodily pain at 3 and 6 month	2.03	1.11	-0.450		0.203	<0.0001
Baseline SF36-MH	61.62	18.15	0.436		0.190	<0.0001
Baseline bodily pain	3.9	0.99	0.118		0.014	0.1642
Age	42.84	10.07	0.042		0.002	0.623
			1 year SF36-MH
Categorical variables	Category	n	Mean	STD
Sex	Male	86	74.88	20.34	0.001	0.724
	Female	55	73.60	21.92
Workers' compensation	Yes	42	68.00	25.05	0.040	0.018
	No	99	77.09	18.44
Crossover	0 month	120	76.83	18.54	0.079	0.001
	3 or 6 month	21	60.38	28.03
	R² from the model including all above variables				0.435

Note: R² was calculated using the model including only one variable.
In covariate selection, linear regression with backward selection method (p = 0.1) was applied, where 1 year SF-36 MH was the dependent variable; age, sex, workers' compensation, baseline bodily pain, prior episodes, and the SF-36 General Health, Vitality, Social Function, and Emotional Role subscales were independent variables; and age, sex and workers' compensation were fixed in the model.
141 of 162 surgical patients with both 1 year mood data and all 7 covariates and DNA were used in the 1 year mood analysis.
"Crossover" refers to the time point when a questionnaire showed that a patient who initially chose nonsurgical treatment underwent lumbar discectomy.

ISSN: 1744-8069