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Figure 3 | Molecular Pain

Figure 3

From: Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)

Figure 3

Intrathecal injection of the MEK inhibitor, U0126, reduces thermal hyperalgesia in wild type mice. A) Effect of intrathecal injection of vehicle (7.5 % DMSO in PBS, pH 7.4) or U0126 (2 nmols) on thermal thresholds in mice. B) Effect of intrathecal pretreatment of either vehicle or U0126 (2 nmols) 15 min prior to injection of 5 % formalin in the hind paw on thermal thresholds recorded 1 hr after formalin injection. n = 10 per group. *p < 0.05.

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