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Figure 5 | Molecular Pain

Figure 5

From: Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)

Figure 5

Reduced phospho-ERK in DN MEK mice spinal cords 15 minutes after 2 % formalin injection in the hind paw. A, Representative immunoblots of ipsilateral (ipsi) and contralateral (contra) mouse spinal cord homogenates from a wild type or a DN MEK mouse using a phospho-ERK 1/2 antibody (top) or a total ERK 1/2 antibody (bottom). B, Quantification of ERK1 and ERK2 bands. Phospho-ERK bands were densitized and normalized to total ERK bands and expressed as % change of phospho-ERK on the ipsilateral side compared to the contralateral side (100 %). ***p < 0.001, significant differences between ipsilateral phospho-ERK and contralateral phospho-ERK. #p < 0.05, significant differences in ipsilateral phospho-ERK between the wild type and DN MEK mice. n = 12 (wild type) and 7 (DN MEK).

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Molecular Pain

ISSN: 1744-8069

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