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Figure 7 | Molecular Pain

Figure 7

From: Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)

Figure 7

Reduced effect of the MEK inhibitor, PD 98059, on A-type potassium currents in spinal cord dorsal horn neuronal cultures from DN MEK mice. A) Representative examples of IA recorded before and after 5 minute bath application of 20 μM of PD 98059 (A-type currents were isolated from sustained currents as described in the methods section). B) Summary of percentage changes of peak amplitude of IA by PD 98059. n = 5 neurons from 4 mice per group. **p < 0.01, ***p < 0.001, significant differences from vehicle treatment. ##p < 0.01, significant differences between wild type and DN MEK mice.

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Molecular Pain

ISSN: 1744-8069

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