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Figure 5 | Molecular Pain

Figure 5

From: Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-κB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

Figure 5

Inhibition of NF-κB prevents the up-regulation of mGlu2 mRNA induced by L-acetylcarnitine treatment. CAPE (2.5 μg/ml) was applied to DRG cultures 30 minutes before L-acetylcarnitine (LAC) (250 μM). 1 hr after LAC treatment total RNA was extracted. mRNA levels were normalized to the housekeeping gene, GAPDH, and compared to controls. Real-time PCR analysis shows that mGlu2 mRNA upregulation induced by LAC is blocked by CAPE treatment. Data are expressed as mean values ± SEM *p < 0.05 vs controls, #p < 0.05 vs LAC (ANOVA).

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Molecular Pain

ISSN: 1744-8069

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