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Figure 6 | Molecular Pain

Figure 6

From: Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-κB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

Figure 6

Acetylation of p65/Rel-A induced by L-acetylcarnitine treatment. p65/Rel-A was immunoprecipitated from DRG cultures after L-acetylcarnitine (A) or carnitine (B) treatment. Western blots show immunoreactivity for anti-acetyl-lysine (red fluorescence) and anti-p65 (green fluorescence). A single red band migrating at ~65 kDa was identified on Western blots. Western blots demonstrate that L-acetylcarnitine (A), but not carnitine (B) treatment induces acetylation of the p65/Rel-A protein. (C) Results are expressed as ratio of integrated intensity of acetyl-lysine and p65 bands. *p < 0.05 vs controls (Student's t test).

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